The documentation for Nginx and UWSGI is long and complex, but with ubuntu 14 it's actually pretty straightforward to get them up and running.

I present here a a setup that uses nginx and uwsgi emperor to host multiple python web applications simultaneously on an ubuntu 14 machine.

First, the packages

$ sudo apt-get install nginx
$ sudo apt-get install uwsgi uwsgi-emperor uwsgi-plugin-python

Our configuration files will now be under /etc/nginx and /etc/uwsgi-emperor

You can start, stop, and reload nginx as follows:

$ sudo service nginx start
$ sudo service nginx stop
$ sudo service nginx reload

The last command is useful when changing configuration settings.

Now set up a site by creating a file in /etc/nginx/sites-available

#/etc/nginx/sites-available/mysite
server{

    server_name     your_host_name;

    location /app1 {
        uwsgi_pass unix:/tmp/app1.socket;
        include uwsgi_params;
    }
    location /app2 {
        uwsgi_pass unix:/tmp/app2.socket;
        include uwsgi_params;
    }
}

Then,

$ sudo ln -s /etc/nginx/apps-available/mysite /etc/nginx/sites-enabled

Next, set up your 'vassals' (http://uwsgi-docs.readthedocs.org/en/latest/Emperor.html)

Create /etc/uwsgi-emperor/vassals/app1.ini as follows:

[uwsgi]
plugin = python
processes = 2
socket = /tmp/app1.socket
chmod-socket = 666

chdir = /srv/app1
wsgi-file = /srv/app1/main.py

uid = www-data
gid = www-data

And for your second application, create /etc/uwsgi-emperor/vassals/app2.ini as similarly:

[uwsgi]
plugin = python
processes = 2
socket = /tmp/app2.socket
chmod-socket = 666

chdir = /srv/app1
wsgi-file = /srv/app2/main.py

uid = www-data
gid = www-data

The simple act of creating or touching a .ini file in /etc/uwsgi-emperor/vassals will cause the emperor process to try to restart your application.

Of course, your applications don't exist yet, so let's create them. The simplest wsgi application can be only a few lines long:

Create /srv/app1/main.py

def application(env, start_response):
    start_response('200 OK', [('Content-Type','text/html')])
    return ["Hello World, I am app1"]

And /srv/app2/main.py

def application(env, start_response):
    start_response('200 OK', [('Content-Type','text/html')])
    return ["I, however, am app2. "]

And that's it!

Visiting http://your_host_name/app1 or http://your_host_name/app2 should return the text you put in the python files.